The Mitsui & Co. Environment Fund
Introduction to Grant Projects
Takahiro Arima, Professor, Tohoku University School of Medicine
Assessment of exposure to organochlorine compounds and the risk to the health of the next generation —A regional revitalization project to indicate fetal and newborn growth and development—
- Project Description
Coastal areas were contaminated with sea bottom sediments, heavy oil and other substances by the tsunami after the Great East Japan Earthquake, and there are concerns about people being exposed to these. Persistent Organic Pollutants (POPs) do not easily break down, but tend to accumulate will remain in the environment and be serious source of pollution. In this application, we propose confirming whether people have been exposed to these, mainly in Ishinomaki City which has an industrial area, and an empirical epidemiological investigation of pregnant women and their babies, who are the most vulnerable to exposure to POPs.
- Grant year
- FY2011 Research Grants
- Grant term
- 3 years
October 2011 - September 2014
- Grant amount
- 15,954,000 yen
- Activity region
- Ishinomaki City, Miyagi Prefecture, Japan
Overview of the Organization
- Takahiro Arima, Professor
- Specialist fields
Obstetrics and gynecology, molecular biology
Affiliated academic societies
Japan Society of Obstetrics and Gynecology, Japanese Cancer Association, The Japan Society of Human Genetics, International Federation of Placental Association, The Molecular Biology Society of Japan, Japan Society for Repor-Regeneral Medicine
Associate (medical doctor) at a hospial affiliated to the Medical Institute of Bioregulation, Kyushu University, 1993; Wellcome CRC Laboratory, Cambridge University, UK, 1998; Assistant, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 2001; COE Independent Fellow, Tohoku University School of Medicine, 2006; Associate Professor, Clinical Research, Innovation and Education Center, Tohoku University Hospital, 2008; Professor, Graduate School of Environmental Genetics Medical Center, Tohoku University School of Medicine
- WEB site
- Nobuo Yaegashi, Professor, Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine; Junichi Sugawara, Lecturer, Perinatal Studies, Tohoku University Graduate School of Medicine; Naoyuki Kurokawa, Lecturer, Miyagi University of Education
- Research record
- (1) Watanabe T, Tomizawa S, Mitsuya K, Totoki Y, Yamamoto Y, Kuramochi-Miyagawa S, Iida N, Hoki Y, Murphy P.J, Toyoda A, Gotoh K, Hiura H, Arima T, Fujiyama A, Sado T, Shibata T, Nakano T, Lin H, Ichiyanagi K, Soloway P.D, Sasaki H. Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 332: 848-852, 2011.
- (2) Sato A, Hiura H, Okae H, Miyauchi N, Abe Y, Utsunomiya T, Yaegashi N, Arima T. Assessing loss of imprint methylation in sperm from subfertile men using novel methylation PCR-Luminex analysis. Fertility and Sterility 95: 129-134, 2011.
- (3) Kobayashi H, Sato A, Otsu E, Hiura H, Tomatsu C, Utsunomiya T, Sasaki H, Yaegashi N, Arima T. Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. Human Mol Genet. 16: 2542-51, 2007.
- (4) Sato A, Otsu E, Negishi H, Utsunomiya T, Arima T. Aberrant DNA methylation of imprinted loci in superovulated oocytes. Human Reproduction. 22:26-35, 2007.
- (5) Arima T, Hata K, Tanaka S, Kusumi M, Li E, Kato K, Shiota K, Sasaki H, Wake N. Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Devel. Biol. 297: 361-73, 2006.